Know-how

Competences and equipments available in the laboratory focus on the study of relationship between bone and marrow adiposity, and on the consequences on bone diseases pathogenesis especially during the anorexia nervosa, femoral head osteonecrosis, and osteonecrosis of the jaw. These phenomenons are studied from bed to bench, with different scales, from molecular aspects to clinical consequences:

·         Molecular biology equipment
·         Cellular biology equipment
·         Biochemistry bone lipids
·         Bone Raman spectrometry
·         Bone marrow RMN spectrometry
·         Undecalcified bone microscopy
·         Murine DEXA (Double Energy X Ray Absorptiometry) (PIXImus)
·         Osteoporosis in Anorexia nervosa
·         Femoral Head osteonecrosis
·         Osteonecrosis of the jaws

microscanner : mandibule de rat         os3d.jpg

Microscanner

   TibiaProx_Bleu deToluidine

Undecalcified bone histomorphometry

 

colorationalp.jpg  adipooilred.jpg

  Osteoblastic differentiation                           Adipocyte differentiation